Ontogenesis of Immune Capability of Murine Bone Marrow Cells and Spleen Cells against Transplantation Antigens
Open Access
- 1 October 1969
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 103 (4) , 683-686
- https://doi.org/10.4049/jimmunol.103.4.683
Abstract
Bone marrow and spleen cell suspensions from C57BL/6 mice were tested for immune competence against transplantation antigens present in B6D2F1 hybrid mice. The test system was the Simonsen GVH spleen weight-gain assay. C57BL/6 mice, which ranged in age from newborns to adults, were the cell donors. Spleen cells first developed immune competence against transplantation antigens when the donor mice were between 6 and 8 days of age. Bone marrow cells failed to exhibit apparent immune competence at any age, with the cell dose employed, and as measured in this bioassay.Keywords
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