MUSCLE HEMOGLOBIN

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Abstract
"Muscle Hb occurs in those muscles requiring vigorous repetitive activity which must be maintained. Its conc. increases with age and activity. It can be obtained in crystalline form, is a true Hb, but differs from blood Hb quantitatively in the following ways its absorption bands are displaced to the red; it has a very high O2 affinity, and a hyperbolic dissociation curve; it has only one Fe atom per molecule; it has a very small Bohr effect; and it has a low affinity for CO relative to O2. There is no evidence that muscle Hb acts catalytically, though its properties are intermediate between those of the blood Hb and oxidation enzymes. It does act as a short-time O2 store, tiding the muscle over from one contraction to the next. As an indicator of O2 tension in the cell, muscle Hb enables the time course of O2 uptake during rest, contraction, and recovery to be followed. It is found that O2 demand rises instantaneously during contraction, the bulk of all the O2 needed being utilized in less than one sec. from the time the work is performed.".

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