Et3GeNa Promoted Formation of Trifluoromethyl Anion Species from C6H5SCF3: Effective Nucleophilic Trifluoromethylation of Various Aldehydes
- 31 December 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (12) , 1191-1192
- https://doi.org/10.1055/s-1996-5720
Abstract
We developed the effective formation of trifluoromethyl anion species from C6H5SCF3 by use of Et3GeNa. Various substrates, such as, alkyl, aryl and unsaturated aldehydes could be transformed to the corresponding α-trifluoromethylated carbinols in good to excellent yields under this reaction condition. This trifluoromethylation proceeded smoothly by use of only Et3GeNa/C6H5SCF3 combination.Keywords
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