ANTITUBERCULOUS IMMUNITY INDUCED IN MICE BY VACCINATION WITH KILLED TUBERCLE BACILLI OR WITH A SOLUBLE BACILLARY EXTRACT

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Abstract
It proved possible to increase the resistance of mice to tuberculous infection by vaccinating them with a suspension of avirulent tubercle bacilli killed by exposure to 2 per cent phenol. This increase in resistance was demonstrated by two different techniques: (a) observation of survival time of vaccinated animals following challenge infection with a large dose of virulent bacilli, and (b) determination of numbers of virulent bacilli in the spleens of animals 2 weeks after injection of a small infective dose.