COMPARISON OF THE SUBECTIVE EFFECTS AND PLASMA CONCENTRATIONS FOLLOWING ORAL AND I.M. ADMINISTRATION OF FLUNITRAZEPAM IN PATIENTS

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Abstract
The use of flunitrazepam 1 and 1.5 mg was compared as a pramedicant with diazepam 10 mg and lorazepam 2.5 mg. Plasma flunitrazeporn concentrations wcre measured after oral and i.m. administration. Flunitrazepam and diazepam had a similar onset time and duration of action, both being more rapid in onset and shorter in duration than lorazepam. I.m. flunitrazepam had a slightly greater sedative effect than oral flunitrazepam and plasma concentrations correlated well with the onset of the sedative effect by either route of administration. The i.m. injection of flunitrazepam was not as painful as that of diazepam, but slightly more painful than lorazepam. A second peak occurred at about 5 h and flunitrazepam still detectable at 48 h. The plasma half-life was 3–4h.

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