SERUM IMMUNOGLOBULIN LEVELS IN ATOMIC BOMB SURVIVORS IN HIROSHIMA, JAPAN1

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Abstract
Serum immunoglobulins were evaluated on 803 atomic bomb survivors and matched controls with respect to their past exposure to ionizing radiation and past medical record of 15 to 22 years. Mean serum IgG and IgA levels were higher than those reported for Americans. Age and sex influenced immunoglobulin levels. With advancing age, IgG and IgA increased in males, and IgM decreased in females. Among clinical abnormalities associated with altered patterns, elevated sedimentation rates and increased lymphocytes were accompanied by significantly increased immunoglobulin levels. Levels were higher in the presence of radiologic evidence of tuberculosis. Mean IgG levels were higher in those exposed to radiation compared to controls. This was statistically significant only for females.

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