Steroid Hormone Regulation of Prostatic Acid Phosphatase Expression in Cultured Human Prostatic Carcinoma Cells
- 1 January 1985
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 366 (2) , 1033-1040
- https://doi.org/10.1515/bchm3.1985.366.2.1033
Abstract
We have investigated the modulation of prostatic acid phosphatase expression in the human prostatic cancer cell line LNCaP in response to the natural androgens testosterone and dihydrotestosterone, the female sex steroid estradiol and the synthetic androgen R1881 (methyltrienolone). Testosterone and dihydrotestosterone at 1 .mu.g/ml enhance the acid phosphatase synthesis by a factor of 3.5, while a hundred-fold lower concentration of the synthetic androgen R1881 induces an almost five-fold increase in the expression of this enzyme. The stimulation by all androgens tested and estradiol was dose-dependent. The synthetic glucocorticoid triamcinolone acetonide does not modulate the prostatic acid phsophatase expression in LNCaP cells, neither alone nor in combination with R1881.This publication has 26 references indexed in Scilit:
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