DYNAMICS OF INSULIN-SECRETION IN RESPONSE TO GLUCOSE BY ISOLATED ISLETS FROM FETAL RATS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 288  (20) , 1567-1570
Abstract
Isolated islets of Langerhans from 21.5 day old fetal rats were studied in a perifusion system in vitro. The overall dyanamics of insulin release by the fetal islets in response to 13.9 mM glucose is biphasic and qualitatively similar to that obtained with islets of adult rats. The magnitude of the initial phase of insulin secretion is similar for the fetal and adult islets. The 2nd phase is 4-fold higher in the adult than in the fetus. The response of fetal islets occurs 45-60 s after the increase of glucose concentration in the medium and a maximum insulin release for the 1st phase is obtained with a lag period of 2 min. The difference between fetal and adult islets is essentially quantiative.

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