Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity.
- 1 January 1992
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 45 (12) , 1892-1898
- https://doi.org/10.7164/antibiotics.45.1892
Abstract
A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline.Keywords
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