Uridine kinase in embryonic rat liver. Modulation of enzyme activity by 5-azacytidine
- 1 August 1973
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 133 (4) , 609-613
- https://doi.org/10.1042/bj1330609d
Abstract
Uridine kinase activity in rat liver decreases during embryonic and postnatal development. Administration of 5-azacytidine enhances liver uridine kinase activity in adult rats, but depresses it in embryos. The liver enzymes from the foetus and the adult are precipitated at different (NH4)2SO4 concentrations although they are eluted at about the same position on chromatography on a column of Sepharose 6B.Keywords
This publication has 17 references indexed in Scilit:
- Properties of Thymidine Kinase Partially Purified from Human Fetal and Adult TissueJournal of Biological Chemistry, 1972
- Enhanced uridine kinase and RNA synthesis in regenerating rat liver after 5-azacytidine administrationArchives of Biochemistry and Biophysics, 1972
- Activity and distribution of the enzymes of uridylate synthesis from orotate in animal tissuesBiochimica et Biophysica Acta (BBA) - Enzymology, 1972
- Cerebral cortex of the mouse after prenatal chemical insultJournal of Anatomy, 1971
- Multiple forms of uridine kinase in normal and neoplastic rat liverBiochemical Journal, 1971
- Enhanced Stability of Uridine Kinase from Mouse Leukemic Cells Resistant to 5‐AzacytidineEuropean Journal of Biochemistry, 1971
- Association of decreased uridine and deoxycytidine kinase with enhanced RNA and DNA polymerase in mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.1970
- Effect of combination treatment with 5-azacytidine and cytidine on the life-span and spleen and bone marrow cells of leukemic (L1210) and nonleukemic mice.1970
- Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor.1969
- Partial reversal of toxic effects of 5-azacytidine by 6-azauridine in normal miceCellular and Molecular Life Sciences, 1965