Monoclonal Origin of Acute Transformation of Chronic Myelogenous Leukemia
- 1 January 1973
- journal article
- Published by S. Karger AG in Acta Haematologica
- Vol. 49 (5) , 300-305
- https://doi.org/10.1159/000208417
Abstract
In a case of chronic myelogenous leukemia with an acquired sex chromosome mosaic (45, XO, PhV46, XY, Ph1), variant cells, developed after blast crisis, were evidenced to have been originated from a 46, XY, Ph1+ clone because of the constant presence of a Y chromosome in them. This strongly suggests that acute transformation has occurred selectively in a single clone.Keywords
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