Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
- 20 April 2005
- journal article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 5 (5) , 413-420
- https://doi.org/10.1038/nri1600
Abstract
The intestinal immune system faces an extraordinary challenge from the large numbers of commensal bacteria and potential pathogens that are restrained by only a single layer of epithelial cells. Here, I discuss evidence that the intestinal immune system develops an extensive network of inducible, reversible lymphoid tissues that contributes to the vital equilibrium between the gut and the bacterial flora. I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development.Keywords
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