The structure of arachidonic and linoleic acids

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Abstract
The products obtained on ozonolysis of methyl arachidonate and on its oxidation with KMnO4 in acetone soln. confirm the formula originally suggested for arachidonic acid by Dolby, Nunn and. Smedley-MacLean (Biochem. Jour., 1940, 34, 1422). Contrary to the results of Takahashi (J. chem. Soc. Japan, 1921, 130) ozonolysis of ethyl linoleate yields products in accordance with the generally accepted structure for linoleic acid. The 11 terminal carbon atoms of arachidonic and linoleic acids are therefore identically linked and this renders probable the synthesis of arachidonic from linoleic acid in the animal body, biological evidence for which has already been brought forward.