RELATION OF THE STREPTOCOCCUS LACTIS R FACTOR TO "FOLIC ACID"
- 8 December 1944
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 100 (2606) , 522-523
- https://doi.org/10.1126/science.100.2606.522
Abstract
Folic acid is formed when S. lactis R is grown in a folic acid-free medium containing the S. lactis R (SLR) factor. The culture, cells or culture fluid, when added to folic acid-free media, support growth and fermentation of Lactobacillus casei and other folic acid-requiring lactic acid bacteria. SLR factor can not replace folic acid for the lactobacilli. However, growth of S. lactis ,in an SLR factor medium allows considerable folic acid formation. The SLR factor, per se, is probably transformed into folic acid. S. fecalis 732, S. fecalis F24, S. zymogenes SC1 and S. durans 98A develop with either SLR factor or folic acid. Lactobacilli do not utilize SLR factor and must obtain folic acid. Most strains tested do not require either factor since they synthesize folic acid. The rate of conversion of SLR factor to folic acid is very rapid. The SLR factor does not form folic acid when incubated with rat-liver suspensions.This publication has 1 reference indexed in Scilit:
- Isolation of a New Lactobacillus casei FactorScience, 1944