STUDIES ON THE BACTERIOPHAGE OF D'HERELLE: VI. ON THE VIRULENCE OF THE OVERGROWTH IN THE LYSED CULTURES OF BACILLUS PESTIS CAVIAe (M. T. II).

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Abstract
Bacteriophage-resistant cultures isolated from overgrowth of lysed cultures proved to be avirulent when administered to mice by feeding or by intraperitoneal injection. These cultures remained resistant to lysis as long as carried on agar, but when transferred to broth they tended to recover susceptibility to lysis and virulence for mice. These findings favor the view that resistant strains result from a selection from variants already existing in the parent culture but do not arise through inheritance of a specific immunity produced by bacteriophage action.