Mechanistic Plasticity of DNA Topoisomerase IB: Phosphate Electrostatics Dictate the Need for a Catalytic Arginine
- 30 April 2005
- Vol. 13 (4) , 513-520
- https://doi.org/10.1016/j.str.2005.02.001
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health (CA78415, GM46330)
This publication has 18 references indexed in Scilit:
- Identification of Specific Nonbridging Phosphate Oxygens Important for DNA Cleavage by Human Topoisomerase IBiochemistry, 2004
- Guarding the Genome: Electrostatic Repulsion of Water by DNA Suppresses a Potent Nuclease Activity of Topoisomerase IBMolecular Cell, 2003
- The mechanism of topoisomerase I poisoning by a camptothecin analogProceedings of the National Academy of Sciences, 2002
- A poxvirus-like type IB topoisomerase family in bacteriaProceedings of the National Academy of Sciences, 2002
- Proton Relay Mechanism of General Acid Catalysis by DNA Topoisomerase IBJournal of Biological Chemistry, 2002
- DNA Topoisomerases: Structure, Function, and MechanismAnnual Review of Biochemistry, 2001
- Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNAScience, 1998
- Mechanism of DNA transesterification by vaccinia topoisomerase: catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167Nucleic Acids Research, 1997
- Histidine 265 Is Important for Covalent Catalysis by Vaccinia Topoisomerase and Is Conserved in All Eukaryotic Type I EnzymesJournal of Biological Chemistry, 1997
- Vaccinia DNA topoisomerase I: Single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactionsBiochemistry, 1994