Cholecystokinin Levels in Prohormone Convertase 2 Knock-out Mouse Brain Regions Reveal a Complex Phenotype of Region-specific Alterations
Open Access
- 1 November 2005
- journal article
- Published by Elsevier
- Vol. 280 (46) , 38410-38415
- https://doi.org/10.1074/jbc.m500055200
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brainJournal of Neurochemistry, 2004
- Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brainJournal of Comparative Neurology, 2003
- Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animalsJournal of Neurochemistry, 2002
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous systemJournal of Comparative Neurology, 2000
- PC2 and 7B2 Null Mice Demonstrate That PC2 Is Essential for Normal Pro-CCK ProcessingBiochemical and Biophysical Research Communications, 2000
- Mitogen-Activated Protein Kinase and Protein Kinase A Signaling Pathways Stimulate Cholecystokinin Transcription via Activation of Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding ProteinMolecular Endocrinology, 1999
- Cell Type-specific Protein-DNA Interactions at the cAMP Response Elements of the Prohormone Convertase 1 PromoterPublished by Elsevier ,1997
- Transcriptional Regulation of the Human Cholecystokinin Gene: Composite Action of Upstream Stimulatory Factor, Sp1, and Members of the CREB/ATF-AP-1 Family of Transcription FactorsDNA and Cell Biology, 1996
- Extra-hippocampal projections of CCK neurons of the hippocampus and subiculumPeptides, 1983