ANALYTICAL CLINICAL-CHEMISTRY PRECISION - STATE OF ART FOR 14 ANALYTES

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (1) , 130-141
Abstract
Relationships of concentration and coefficient of variation for 14 clinical chemistry analytes are described. Estimated mean regression curves and SD of individual laboratory coefficients of variation about the mean regression are calculated. Two analytes, Ca2+ and Na+, showed no relationship of concentration to precision. Twelve analytes showed significant relations between concentration and coefficient of variation. State-of-the-art precision is compared with medical goals. The average coefficient of variation for one analyte, Ca2+, fails to meet medical goals for automated or manual methods. Average precisions for 13 analytes meet medical goals. The distribution of individual laboratory precision above average state-of-the-art figures is discussed. The proportions of laboratories failing to meet medical goals are large for Na+, Cl- and glucose, in addition to Ca2+.

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