β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF SHORTENED PEPTIDE CHAINS
- 1 February 1978
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 11 (2) , 154-158
- https://doi.org/10.1111/j.1399-3011.1978.tb02834.x
Abstract
Three analogs of beta-endorphin have been synthesized by the solid-phase method: betac-endorphin-(1--5)-(28--31), betac-endorphin-(6--31) and betah-endorphin-(1--5)-(16--31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than beta-endorphin. These data suggest that the entire beta-endorphin molecule is necessary for full in vivo analgesic activity.Keywords
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