KIDNEY TRANSPLANTATION ACROSS POSITIVE B AND T CELL CROSSMATCHES

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Abstract
Cadaveric renal transplants were performed despite a positive conventional crossmatch (usually intermediate positive) resulting from donor-specific B [bone marrow derived] cell lymphocytotoxins (Ig[immunoglobulin]G and IgM) or IgM cold-reactive T [thymus derived] cell lymphocytotoxins. Graft survival at 2 mo. was 72% in the 14 patients with B cell-specific antibodies and 71% in the 7 recipients with T cell antibodies. No correlation was observed between graft rejection and warm (mainly IgG) or cold (IgM) B cell-specific antibodies. Apparently not all positive crossmatches are a contraindication to transplantation. Attempts should be made to study the nature of the lymphocytotoxins before withholding the allograft from the recipient.

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