Brucella Abortus Lipopolysaccharide Is Mitogenic for Spleen Cells of Endotoxin-Resistant C3H/HeJ Mice
Open Access
- 1 December 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 123 (6) , 2915-2919
- https://doi.org/10.4049/jimmunol.123.6.2915
Abstract
Preparations of lipopolysaccharide (LPS) from rough and smooth strains of Brucella abortus were mitogenic for spleen cells of athymic nude mice, C3H/HeAU mice, and the endotoxin-resistant C3H/HeJ mice. The mitogenic response induced by crude smooth-LPS (f5) was greater than that produced by purified smooth-LPS (f5p); however, the dose-response curves were similar for both preparations. The mitogenic activity of mouse spleen cells to both f5 and f5p was higher than that produced by stimulation with purified rough-LPS. The dose-response curves with rough-LPS were also qualitatively different from those produced with the preparations of smooth-LPS.This publication has 2 references indexed in Scilit:
- A new and improved microassay to determine 2-keto-3-deoxyoctonate in lipopolysaccharide of gram-negative bacteriaAnalytical Biochemistry, 1978
- Chemical Composition and Biological Properties of the Endotoxin ofBrucella abortusJournal of Bacteriology, 1965