Decreased NK activity in hairy cell leukemia (HCL): An analysis at the cellular level
- 1 August 1986
- journal article
- conference paper
- Published by Springer Nature in Annals of Hematology
- Vol. 53 (2) , 107-113
- https://doi.org/10.1007/bf00321093
Abstract
Peripheral blood lymphocytes (PBL) of eleven patients with Hairy Cell Leukemia were studied for surface phenotype and for NK activity against the K 562 cell line (using both the standard 51Cr Release Assay and the Single Cell Cytotoxicity Assay on poly-L-lysine coated coverslips). A significant reduction in NK activity, target binding cells (TBC) and NK active cells (NKa) was detected. In some cases however, despite a very low percentage of NKa, residual NK activity was observed, suggesting an efficient recycling capacity.Keywords
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