Severe atypical endometrial changes and sequential contraceptive use

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Abstract
Of 8 young women, 7 had a diagnosis of well-differentiated endometrial adenocarcinoma and 1 had atypical endometrial hyperplasia. The average age was 40.1 yr, with 6.04 yr of dimethisterone-ethinyl estradiol (Oracon) sequential contraceptive use. The patients were not typical of those in whom endometrial carcinoma develops. Although these cases do not prove that long-term administration of dimethisterone-ethinyl estradiol causes endometrial adenocarcinoma or atypia, they indicate that it may do so.

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