Current and future challenges in the design and analysis of cluster randomization trials
- 20 December 2001
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 20 (24) , 3729-3740
- https://doi.org/10.1002/sim.1115
Abstract
Randomized trials in which the unit of randomization is a community, worksite, school or family are becoming widely used in the evaluation of life‐style interventions for the prevention of disease. The increasing interest in adopting a cluster randomization design is being matched by rapid methodological developments. In this paper we describe several of these developments. Brief mention is also made of issues related to economic analysis and to the planning and conduct of meta‐analyses for cluster randomization trials. Recommendations for reporting are also discussed. Copyright © 2001 John Wiley & Sons, Ltd.Keywords
This publication has 45 references indexed in Scilit:
- Effectiveness of paramedic practitioners in attending 999 calls from elderly people in the community: cluster randomised controlled trialBMJ, 2007
- Are distinctive ethical principles required for cluster randomized controlled trials?Statistics in Medicine, 2001
- Binary data with two, non-nested sources of clustering: an analysis of physician recommendations for early prostate cancer treatmentBiostatistics, 2000
- Marginalized multilevel models and likelihood inference (with comments and a rejoinder by the authors)Statistical Science, 2000
- The WHO Antenatal Care Randomised Controlled Trial: rationale and study designPaediatric and Perinatal Epidemiology, 1998
- Outliers in Multilevel DataJournal of the Royal Statistical Society Series A: Statistics in Society, 1998
- Sample Size and Power Calculations for Periodontal and Other Studies with Clustered Samples Using the Method of Generalized Estimating EquationsBiometrical Journal, 1997
- A Crossed Random Effects Model for Unbalanced Data with Applications in Cross-Sectional and Longitudinal ResearchJournal of Educational Statistics, 1993
- Vitamin A supplementation and child survivalThe Lancet, 1992
- Some considerations for the planning of total-community prevention trials-when is sample size adequate?Journal of Community Health, 1980