Production and isolation of siderophores from the soil fungus Epicoccum purpurascens

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Abstract
A large number of Fe transport agents, siderophores, were isolated during a study of the antitumor activity associated with the metabolic products of the fungus E. purpurascens. The production of the siderophores was significantly enhanced in a variety of media by culture of the fungus in the near absence of ferric iron. A novel method of purification involving a carboxylic ion-exchange resin separated the siderophores into 4 subgroups. The 1st subgroup, which contained the majority of the activity, was subsequently resolved in a similar manner with the carboxylic resin into 7 individual siderophores. Of these, 2 were characterized as ferricrocin and coprogen; the others appeared to represent new compounds. One of the latter was given the name triornicin and exhibited slight antitumor activity in mice injected with Ehrlich ascites tumor cells.