The effect of smoking in pregnancy on maternal serum inhibin A levels
- 26 April 1999
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 19 (4) , 372-374
- https://doi.org/10.1002/(sici)1097-0223(199904)19:4<372::aid-pd537>3.0.co;2-o
Abstract
To assess the effect of smoking on maternal serum, second‐trimester inhibin A levels, we studied a database of 1277 women undergoing antenatal serum screening. There were 75 smokers, 1008 non‐smokers and 194 women in whom smoking status was undetermined. All groups were matched for age, gestation and parity. The median level of inhibin A in smokers was 1·47 multiples of the normal gestation‐specific median (MOM) as compared with 1·01 MOM in non‐smokers and 0·95 MOM in the undetermined group. The increase was highly statistically significant (p<0·0001, Wilcoxon rank sum test, two‐tail). On the basis of these results we conclude that if inhibin A is used as a marker, adjustment for maternal smoking status may be necessary. Copyright © 1999 John Wiley & Sons, Ltd.Keywords
This publication has 15 references indexed in Scilit:
- α-Fetoprotein, free β-human chorionic gonadotropin, and dimeric inhibin A produce the best results in a three-analyte, multiple-marker screening test for fetal Down syndromeAmerican Journal of Obstetrics and Gynecology, 1997
- Activin A and inhibin A as possible endocrine markers for pre-eclampsiaThe Lancet, 1997
- COMBINING INHIBIN A WITH EXISTING SECOND-TRIMESTER MARKERS IN MATERNAL SERUM SCREENING FOR DOWN'S SYNDROMEPrenatal Diagnosis, 1996
- Dimeric Inhibin A as a Marker for Down's Syndrome in Early PregnancyNew England Journal of Medicine, 1996
- Second trimester screening for Down's syndrome using maternal serum dimeric inhibin AClinical Endocrinology, 1996
- Inhibin in normal and abnormal pregnancy: Maternal serum concentration and partial characterizationAmerican Journal of Obstetrics and Gynecology, 1995
- Relation between maternal haemoglobin and placental hormone concentrations in early pregnancyThe Lancet, 1994
- Adjustment formulae for maternal serum alpha‐fetoprotein, human chorionic gonadotropin, and unconjugated oestriol to maternal weight and smokingPrenatal Diagnosis, 1993
- The effect of smoking in pregnancy on maternal serum alpha‐fetoprotein, unconjugated oestriol, human chorionic gonadotrophin, progesterone and dehydroepiandrosterone sulphate levelsBJOG: An International Journal of Obstetrics and Gynaecology, 1990
- Cigarette smoking in pregnancy results in marked decrease in maternal hCG and oestradiol levelsBJOG: An International Journal of Obstetrics and Gynaecology, 1989