MECHANISM OF EFFECT OF ESTROGEN ON NASAL MUCOSA IN ATROPHIC RHINITIS: Successful Treatment with Prostigmine Methylsulfate; A Further Report

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Abstract
The local treatment of atrophic rhinitis with estrone has been described by Mortimer, Wright and Collip.1 The use of this substance for the treatment of ozena was suggested to them by their observations of periodic changes in the appearance of the nasal mucosa during menstruation. Oily solutions of estrone were repeatedly sprayed onto the nasal mucous membranes, and clinical improvement was reported. Blaisdell,2 noting a similarity in the pathologic changes of atrophic rhinitis and of atrophic vaginitis, arrived at a like idea for the treatment of this entity. He also reported clinical improvement achieved through intranasal estrone therapy. One of us (S. S.) made an endocrinologic study of a number of patients with advanced atrophic rhinitis and failed to find evidences of the endocrine disturbances described by Collip and his co-workers. Furthermore, treatment of these patients with intranasal estrone produced only mildly favorable or negative results. These two facts depreciated

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