Proton Magnetic Resonance Spectroscopy of Vascular- and Alzheimer-Type Dementia
- 1 July 1996
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 53 (7) , 678-680
- https://doi.org/10.1001/archneur.1996.00550070116019
Abstract
Objective: To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia. Design and Subjects: Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia. Results: The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P<.02). Conclusion: Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.Keywords
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