IMMUNOPATHOLOGY OF SKIN IN ACUTE POST-STREPTOCOCCAL GLOMERULONEPHRITIS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 102  (10) , 522-526
Abstract
The immunohistologic features of the skin were studied in 26 cases of poststreptococcal glomerulonephritis. Twenty-two patients had vascular and extravascular dermal deposition of Ig[immunoglobulin]G. Positive stains for C3 [3rd complement component] (8 patients), IgM (2 patients) and fibrinogen (5 patients) were confined to vessel walls. Staining with anti-IgA serum was uniformly negative. Circulating antiskin antibodies could not be detected. Extravascular accumulation of IgG has a widespread distribution in the dermal papillary layer that is highly characteristic. It was absent in 7 patients with chronic glomerulonephritis and in 11 patients with various other renal diseases. The described findings appear to occur consistently in acute poststreptococcal glomerulonephritis. The distinctive extravascular demonstration of IgG may be valuable in the diagnosis of this entity.

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