Nerve Ischaemia‐Resistance: An early Abnormality in Diabetes

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Abstract
Vibration perception threshold (VPT) has been measured before and 30 min after limb ischaemia in 17 newly diagnosed non‐insulin‐dependent diabetic patients and matched controls. Mean baseline VPT was higher in the diabetics than in controls (14 vs 11, pppr = −0.53, pp<0.001), but this bore no relation to changes in ischaemic index.Peripheral nerve ischaemia‐resistance is present at the time of diagnosis of non‐insulin‐dependent diabetes, even in the absence of other neurophysiological abnormalities, and is not explicable by glycaemic control alone.

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