Intraductal carcinoma of the breast: Follow-up after biopsy only

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Abstract
Twenty-eight women with ductal carcinoma in situ (DCIS) of the breast treated by biopsy only were identified in a histologic review of 11,760 biopsies performed between 1950-1968. Seven of the 25 women followed for more than 3 yr developed invasive breast carcinoma, all in the same breast with a previously detected DCIS. Average follow-up interval for the 18 women not developing invasive carcinoma was 16 yr. The invasive carcinomas presented clinically from 3-10 yr (average, 6.1 yr) after the biopsies demonstrating DCIS. Four women with invasive carcinoma developed distant metastases following mastectomy. This study suggests that 28% of women treated with biopsy only for DCIS presenting as an incidental histologic finding will develop invasive carcinoma in a follow-up period of .apprx. 15 yr.