Interleukin 12 in Part Regulates Gamma Interferon Release in Human Whole Blood Stimulated withLeptospira interrogans

Open Access

1 March 2003

journal article
Published by American Society for Microbiology in Clinical and Vaccine Immunology

Vol. 10 (2) , 332-335
https://doi.org/10.1128/cdli.10.2.332-335.2003

Abstract

Heat-killed pathogenicLeptospira interrogansserovar rachmati induced the production of gamma interferon (IFN-γ) and the IFN-γ-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-γ was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.

Keywords

This publication has 20 references indexed in Scilit:

Protective KilledLeptospira borgpeterseniiVaccine Induces Potent Th1 Immunity Comprising Responses by CD4 and γδ T Lymphocytes
Infection and Immunity, 2001
The role of gamma interferon in antimicrobial immunity
Current Opinion in Microbiology, 2001
Leptospirosis
Clinical Microbiology Reviews, 2001
Reduced Th1, but Not Th2, Cytokine Production by Lymphocytes after In Vivo Exposure of Healthy Subjects to Endotoxin
Infection and Immunity, 2000
Elevated Plasma Concentrations of Interferon (IFN)–γ and the IFN‐γ–Inducing Cytokines Interleukin (IL)–18, IL‐12, and IL‐15 in Severe Melioidosis
The Journal of Infectious Diseases, 1999
THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses
Annual Review of Immunology, 1998
Immunobiology of lnterleukin-12
Immunologic Research, 1998
CELLULAR RESPONSES TO INTERFERON-γ
Annual Review of Immunology, 1997
Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.
Journal of Clinical Investigation, 1995
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
Proceedings of the National Academy of Sciences, 1993