Acquired Expression of hst‐1 in an Autonomous Subline (Chiba Subline 2) Derived from Androgen‐responsive Mouse Mammary Tumor (Shionogi Carcinoma 115)

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Abstract
Since growth of Shionogi Carcinoma 115 (SC 115) and its autonomous subline (CS 2) were regulated by fibroblast growth factor‐like peptide, expression of int‐2 and hst‐1 was examined in these cell lines. Hybridization of genomic DNA with long terminal repeat of mouse mammary tumor virus (MMTV) revealed the same pattern of restriction fragments, showing the same integration of MMTV. Although weak expression of int‐2 was noticed in the two cells, clear expression of hst‐1 was seen only in CS 2 cultured with/without testosterone. It is suggested that autonomous growth of androgen‐unresponsive CS 2 is connected with expression of hst‐1.