Decreased glomerular filtration rate in solderers exposed to cadmium.
Open Access
- 1 December 1995
- journal article
- research article
- Published by BMJ in Occupational and Environmental Medicine
- Vol. 52 (12) , 818-822
- https://doi.org/10.1136/oem.52.12.818
Abstract
OBJECTIVES--to evaluate the degree of cadmium induced glomerular impairment and to assess the dose-response relation between cadmium dose and the prevalence of glomerular dysfunction. METHODS--A comparison of glomerular filtration rates (GFR) assessed by Cr-EDTA clearance was made in 42 solderers previously exposed to cadmium for at least five years. Blood and urine data were collected at health examinations in 1984, 1989, and 1993. Individual doses of cadmium were estimated by analysing cadmium in blood. RESULTS--Glomerular lesions induced by cadmium are irreversible and the GFR decreases with the degree of tubular damage. The GFR also decreases with cadmium dose and there is a dose-response relation between blood cadmium and prevalence of glomerular damage with 3.4% prevalence at blood cadmium concentrations below 50 nmol/l, 33% at blood cadmium concentrations between 50 and 75 nmol/l and 100% prevalence of glomerular damage when cadmium in blood exceeds 75 nmol/l. CONCLUSIONS--The kidney lesions induced by cadmium are irreversible and the prevalence of those lesions are dose dependent. There is also evidence of a dose related decrease in GFR even a long time after the end of exposure. Exposure to cadmium should therefore be minimised and workers exposed to cadmium should be examined regularly for many years after the end of exposure.Keywords
This publication has 22 references indexed in Scilit:
- Dose‐response relations between urinary cadmium and tubular proteinuria in cadmium‐exposed workersAmerican Journal of Industrial Medicine, 1994
- Incidence of renal stones among cadmium exposed battery workers.Occupational and Environmental Medicine, 1993
- Renal Function Impairment in Workers Previously Exposed to CadmiumNephron, 1993
- Health significance of cadmium induced renal dysfunction: a five year follow up.Occupational and Environmental Medicine, 1989
- Assessment of renal function in workers previously exposed to cadmium.Occupational and Environmental Medicine, 1985
- β2‐microglobulinuria among workers previously exposed to cadmium: Follow‐up and dose‐response analysesAmerican Journal of Industrial Medicine, 1985
- Long-term observations on tubular and glomerular function in cadmium-exposed persons.Environmental Health Perspectives, 1984
- Biologic indicators of cadmium nephrotoxicity in persons with low-level cadmium exposure.Environmental Health Perspectives, 1984
- Reference values for51Cr-EDTA clearance as a measure of glomerular filtration rateScandinavian Journal of Clinical and Laboratory Investigation, 1981
- A Simple Method for the Determination of Glomerular Filtration RateScandinavian Journal of Clinical and Laboratory Investigation, 1972