O2-flux-optode for medical application

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Abstract
About 1-2% of the basal human O2-consumption is taken up by the skin surface. This amount varies depending on the local skin blood flow. A new sensing device, the O2-flux- optode, has been developed which should allow the measurement of local O2-uptake of the skin and thereby indirectly its local circulation. This luminescence-based-sensor (1) is permeable for the analyte O2, (2) is flexible for covering larger areas of the surface, and (3) does not consume the analyte O2. The new O2-flux-optode consists of an indicator layer with an embedded oxygen sensitive fluorescence dye and a test layer with known diffusion properties. If this sensor is applied to the skin, the pO2 between skin surface and test layer is measured. With defined (or measured) pO2 of the environment (e.g., air) the O2-flux (JO(2)) into the tissue can be determined from the pO2 gradient ((Delta) pO2) across the test layer and its material properties (C). This yields to the equation: JO(2) equals C * (Delta) pO2.

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