Genetic interaction of CTLA‐4 with HLA‐DR15 in multiple sclerosis patients
- 25 June 2003
- journal article
- review article
- Published by Wiley in Annals of Neurology
- Vol. 54 (1) , 119-122
- https://doi.org/10.1002/ana.10617
Abstract
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA‐DRB1*1501‐DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte‐associated antigen 4 (CTLA‐4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family‐based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119–122Keywords
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