The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 2 (9) , 845-849
- https://doi.org/10.1093/carcin/2.9.845
Abstract
After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were higher concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.This publication has 3 references indexed in Scilit:
- Methylation of hamster DNA by the carcinogen N-nitroso-bis (2-oxopropyl)amineCancer Letters, 1981
- Improvement of pancreatic cancer model by modified treatment with N-notrosobis (2-oxopropyl) amineCancer Letters, 1977
- Metabolism of the Pancreatic Carcinogens N -Nitroso-bis(2-oxopropyl)amine and N -Nitroso-bis(2-hydroxypropyl)amine in the Syrian Hamster 2JNCI Journal of the National Cancer Institute, 1976