CALICIVIRUSES INFECTING MONKEYS AND POSSIBLY MAN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (2) , 287-289
Abstract
Caliciviruses were, for the 1st time, shown experimentally to infect a primate. By 24 h after being inoculated with San Miguel sea lion virus (SMSV), an African green monkey [Cercopithecus aethiops] developed a febrile response and vesicular lesions at injection sites. Virus was recovered from lesion material 96 h later and from the stool at 48 h. Possible human infection with SMSV was indicated by serologic evidence. Three persons working with 4 distinct serotypes of SMSV developed neutralizing antibody titers to 2 SMSV types. The positive serum-neutralization test results were confirmed, using immunoelectron microscopy to demonstrate complexes of viruses and antibodies.

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