Effect of Hepatectomy on Serum Lipoproteins in Dogs

Abstract
Hepatectomy in dogs causes no change in the plasma lipoprotein pattern as measured by ultracentrifugation for about 6 hours after operation. Later all lipoproteins and cholesterol began to decrease in spite of hemoconcentration. Qualitatively the lipoprotein pattern was unchanged. Concurrent studies of the electrophoretic plasma protein pattern exhibited decrease in total protein and decrease in alpha-1-globulin after 12 to 16 hrs. These results are interpreted as being due to decreased supply of these plasma components because of utilization by extrahepatic tissues and lack of hepatic synthesis.

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