ROLE OF PROSTAGLANDINS IN CHEMICALLY-INDUCED INFLAMMATION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (6) , 689-695
Abstract
Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, was quantitated using the Evans blue technique of Harada et al. (1971). In control rats and in rats pretreated with indomethacin (an inhibitor of prostaglandin [PG] synthesis) concentration-response lines were obtained for 5-hydroxytryptamine, histamine, bradykinin and PGE1, bradykinin in the presence of PGE1 (10-6 M), 5''-ATP, compound 48/80 [p-methoxyphenethyl methylamine formaldehyde product], capsaicin and AgNO3. In rats pretreated with indomethacin the dye leakage responses to histamine, PGE1, 5''-ATP and AgNO3 were significantly reduced, but no significant changes were observed in the responses to the other irritants. It is suggested that part of the action of histamine, 5''-ATP and PGE1 is produced indirectly by releasor stimulation of the synthesis of PG or their precursors. These results might have important implications in the understanding of the inflammatory response.