EFFECT OF AROMATIC DIAMIDINES ON BLOOD-COAGULATION AND FIBRINOLYSIS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (5) , 635-644
Abstract
The effect of the aromatic diamidine derivative 2,6-bis (4-aminodinobenzyl)-cyclohexanon-(1) on blood coagulation and fibrinolysis in vitro and in vivo [rabbit, mouse] was compared with that of the benzamidine derivative 4-amidinophenyl pyruvic acid and the aromatic diamidine derivative 4,4''-diamidinophenoxypentane. 2,6-Bis(4-amidinobenzyl)-cyclohexanon-(1) was a strong inhibitor of the clotting enzyme thrombin [bovine]. Because of the toxic side effects and pharmacokinetic properties of both diamidine derivatives, their in vivo use as anticoagulants is limited.