HISTAMINE-LIKE SUBSTANCE PRESENT IN NASAL SECRETIONS OF COMMON COLD AND ALLERGIC RHINITIS

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Abstract
Nasal secretions from 22 sufferers of common cold or allergic rhinitis have been investigated for presence of histamine-like substances. The method used was based on Kwiatkowski''s modification of the Barsoum and Gaddum, and of the Code procedures. Whenever possible, the biologic assay was conducted according to the design set forth by Schild, and the results statistically analyzed as outlined by this author. A substance which had histamine-like properties has been found in secretions from allergic rhinitis as well as from common cold. Its concn. varies so widely in both conditions, that it can in no way be used for differentiation. No correlation was found between the number of the eosino-philes present in the secretions and their histamine content.