Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

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Abstract
Resistance to radiation leukemia virus-induced leukemogenesis [in mice] is associated with the H-2D region of the H-2 complex, or with closely linked loci. The H-2Dd allele confers resistance to the disease, while the H-2Dq and H-2Ds alleles are associated with susceptibility. It is not clear whether Ir genes or an alternative mechanism are responsible for the observed H-2-linked resistance to the disease.