The first enantioselective synthesis of trans- and cis-dihydroflavonols

1 January 1996

journal article
research article
Published by Royal Society of Chemistry (RSC) in Chemical Communications

No. 24,p. 2747-2748
https://doi.org/10.1039/cc9960002747

Abstract

Epoxidation of a series of polyoxygenated chalcones with H₂O₂ in the presence of poly(α-amino acid) catalysts, followed by Lewis acid-catalysed phenylmethanethiol ring-opening and cyclization, afforded trans- and cis-dihydroflavonols in moderate to high enantiomeric excess and yield.

Keywords

TRANS AND CIS
CIS DIHYDROFLAVONOLS
POLYOXYGENATED CHALCONES
LEWIS ACID
ACID CATALYSED
HIGH ENANTIOMERIC
AFFORDED TRANS

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