The Causes of Bovine Metestrous Bleeding

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Abstract
Cows ovariectomized on the day of heat or the day following bleed from the uterus as usual but ovariectomy at any other stage of the cycle is not followed by bleeding. It could not be reproduced with regularity when ovariectomized cows were injd. with various doses and combinations of estrogens and progesterone. Prostigmine is not followed by bleeding in the normal cow. Normal bleeding is suppressed by injecting estrogens. The evidence, though not conclusive, suggests an estrogen withdrawal phenomenon. Microscopic bleeding occurs at the 10th day of the cycle. This can be reproduced by estrogen injn. with fair regularity but more so with progesterone. The time relations suggest that the uterus has a 10-day latent period between bleedings. During this time it cannot respond to hormones in this way.

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