THE INFLUENCE OF KAINIC ACID ON THE TUBEROINFUNDI-BULAR DOPAMINERGIC TRACT OF THE RAT: FLUORESCENCE HISTOCHEMISTRY AND ELECTRON MICROSCOPIC INVESTIGATION
- 1 January 1976
- journal article
- research article
- Published by Japan Society of Histochemistry & Cytochemistry in ACTA HISTOCHEMICA ET CYTOCHEMICA
- Vol. 9 (4) , 315-322
- https://doi.org/10.1267/ahc.9.315
Abstract
The degenerative changes in the floor portion of the 3rd ventricle of the rats were investigated by fluorescence histochemistry and EM after administration of an anthelmintic, kainic acid (10-40 mg/kg). Catecholamine fluorescence in the arcuate nucleus and the external layer of the median eminence was markedly depleted and almost disappeared 2 h after administration. Light microscopically, the nerve cells of the arcuate nucleus showed strong vacuolization and pyknotic changes simultaneously. Electron microscopically, the cytoplasmic degenerative changes and massively dilated dendritic profiles were observed in the arcuate nucleus. The dense cored vesicles were decreased in number and electron dense bodies and myelin figures appeared in the nerve endings of the external layer of the median eminence.This publication has 0 references indexed in Scilit: