Experience with Measles Immunization

1 March 1962

journal article
research article
Published by American Medical Association (AMA) in American Journal of Diseases of Children

Vol. 103 (3) , 427-429
https://doi.org/10.1001/archpedi.1962.02080020439055

Abstract

This report deals with the evaluation of a killed alum-adsorbed measles-virus vaccine, No. CT-1199E, prepared in the laboratories of the Eli Lilly Company. The investigation was designed to determine the effect of 1, 2, and 3 subcutaneous injections of 1 ml., given at monthly intervals, and to determine the effect on the neutralizing antibodies of a challenge injection of attenuated live measles-virus vaccine prepared at the Lederle Laboratories, Vaccine No. 7-1236-34, TCID₅₀of 20,000. Neutralizing antibody determinations of the control bloods and of those obtained 1 month after the last killed-vaccine injection were made at the Lilly Laboratories. Standard control sera used contained 100 to 256 units of neutralizing antibody, and the TCID₅₀ranged from 50 to 416. The challenge injections were given 1 month after the killed vaccine. Neutralizing antibody titers of the bloods obtained 1 month after challenge were studied at both the Eli Lilly and

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