Precursor B‐cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis

Publisher Website
Google Scholar
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK‐cell lymphoid neoplasms. HLH with B‐cell malignancies is less common and HLH has rarely been described in association with precursor B‐cell acute lymphoblastic leukemia (B‐ALL). We report three cases of HLH associated with B‐ALL and review 17 cases of ALL‐associated HLH previously reported in the literature. Pediatr Blood Cancer 2008;50:381–383.