Errors in the Processing of Dye Dilution Curves

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Abstract
Errors of two kinds occur in the processing of dye dilution curves: 1) Individual estimates of the decay constant of a dye curve are subject to random errors causing a variability of up to 10% in the calculated cardiac output, and of up to 4% in the estimated vascular volume. 2) The use of an inappropriate numerical integration formula can cause an additional error of up to 5% in the calculated cardiac output. This may be avoided by using either the trapezoid rule or Simpson's rule. The planimeter measures areas with sufficient accuracy for routine determination of cardiac output.

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