Killing the messenger: short RNAs that silence gene expression
Top Cited Papers
- 1 June 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 4 (6) , 457-467
- https://doi.org/10.1038/nrm1129
Abstract
Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.Keywords
This publication has 113 references indexed in Scilit:
- Germline transmission of RNAi in miceNature Structural & Molecular Biology, 2003
- A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined ImmunodeficiencyNew England Journal of Medicine, 2003
- Systematic functional analysis of the Caenorhabditis elegans genome using RNAiNature, 2003
- RNA interferenceNature, 2002
- Effective expression of small interfering RNA in human cellsNature Biotechnology, 2002
- U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cellsNature Biotechnology, 2002
- On the Role of RNA Amplification in dsRNA-Triggered Gene SilencingCell, 2001
- RNAi in Mouse Oocytes and Preimplantation Embryos: Effectiveness of Hairpin dsRNABiochemical and Biophysical Research Communications, 2001
- A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegansScience, 2001
- Heritable and inducible genetic interference by double-stranded RNA encoded by transgenesNature Genetics, 2000